Indeed, besides the main signals from Table 1, our data showed both enrichment for a negative bacterium-disease association (Fig 1B) and significant enrichment for negative effects of IBD risk alleles on all bacteria levels, with 65%, 71%, 70%, and 60% of the associations negative for ATG16L1, CARD9, LRRK2, and NOD2, respectively (Fig 4A–4D, p-values for enrichment equal 7.1x10-5, 3.3x10-8, 1.3x10-8, and 5.3x10-3, respectively). The gene discussed is NOD2; the disease is inflammatory bowel disease.