GPT and liver disorder: The broad consistency of findings between multivariable and MR analyses for each exposure individually, and both jointly, on ALT and GGT provides more compelling evidence for potential causality than either method alone as they each have different key sources of bias.21 Mendelian randomization findings for incident liver disease suggested larger estimates of an association with both BMI and alcohol intake than the observational multivariable findings in multivariable analyses or horizontal pleiotropy exaggerating associations in MR analyses.