Relative to all other covariates, those associated with kidney function (serum creatinine and albumin to creatinine ratio) and cardiovascular disease risk factors (10-year Framingham risk score, total cholesterol, and smoking status) most frequently defined membership in the 6% of subgroups with a higher likelihood of being adversely affected by treatment (eTable 2 in the Supplement). The gene discussed is ALB; the disease is cardiovascular disorder.