DNMT3A and acute myeloid leukemia: Returning to humans, studies of clonal hematopoiesis of the elderly reveal that the spectrum of DNMT3A mutations driving clonal expansions in old age diverges from those associated with leukemias: Non‐R882 mutations make up the majority of mutant DNMT3A clonal hematopoiesis, but represent the minority of DNMT3A mutant acute myeloid leukemias (Atlas, 2013; Buscarlet et al., 2017; Genovese et al., 2014; Jaiswal et al., 2014; McKerrell et al., 2015; Xie et al., 2014), suggesting that the more dominant expansions present substantially less risk of leukemic progression than others.