Everolimus (and another rapalogs) induces apoptosis in a variety of tumours cells: pancreatic cancer (Peng and Dou 2017), ovarian cancer (Guo et al. 2016), colon cancer (He et al. 2016), breast cancer (Du et al. 2018), N-RAS mutant neuroblastoma cell lines (Kiessling et al. 2016), and T cell leukemia/lymphoma in long-term treatment (Darwiche et al. 2011), however in some tumours its high concentration stimulates a caspase-independent pathway – autophagy cell death (Nikoletopoulou et al. 2013; Lui et al. 2016). Here, NRAS is linked to colonic neoplasm.