According to Kim et al. (2010), inhibition of proliferation induced by AS-703026 was mediated by G0-G1 cell cycle arrest and was accompanied by induced apoptosis via caspase-3 and Poly ADP ribose polymerase (PARP) cleavage in multiple myeloma cells, both in the presence and absence of bone marrow stromal cells. This evidence concerns the gene CASP3 and plasma cell myeloma.