Since many current studies searching for effective anticancer treatment focus their efforts on new capabilities of the already registered drugs and their use in combination with other potential ones, the herein study focuses on the effects of protein kinase inhibitors, and in particular the very promising mTOR inhibitor everolimus, on expression of pro-survival Bcl-2 family proteins, caspase-3 activity, and induction of apoptosis in melanoma cells. The gene discussed is CASP3; the disease is melanoma.