The results obtained by He et al. (2016) regarding the use of high concentrations of everolimus (10-25 μM) in colon cancer cells with the BRAF V600E and K-RAS mutation showed that they are unlikely to respond to monotherapy targeting mTOR inhibitor, but might benefit from combination therapy with PI3K, RAF or MEK inhibitors. The gene discussed is MAP2K7; the disease is colonic neoplasm.