Investigated was also the effect of protein kinases’ inhibitors: AKT – MK-2206, MEK – AS-703026, PI3K – LY294002 and ERK1/2 – U126 and mTOR – everolimus in a single mode, and their combinations on caspase-3 activation and proliferation in WM266–4 and WM115 melanoma cell lines. This evidence concerns the gene MAPK3 and melanoma.