Previous studies found that IDH1 mutation is an important prognostic marker in GBM patients and is associated with hypermethylation status of a series of genes.12, 27 By checking the correlation between these two genes and IDH1 mutations, we found that the IDH1 mutation group had significantly lower LGALS3 expression (P < 0.001, Figure 5E). This evidence concerns the gene LGALS3 and glioblastoma.