LGALS3 and liver cancer: Galectin‐3 encoded by LGALS3 gene plays an important role in cell adhesion, growth, differentiation, apoptosis, as well as angiogenesis in both normal and cancerous tissues.14 Its upregulation might serve as a valuable prognostic marker in multiple cancers, such as breast cancer,15 gastric cancer,16, 17 colorectal cancer18 and liver cancer.19 Upregulated LGALS3 was also observed in GBM tissues.20, 21 Galectin‐3–binding protein (Gal‐3BP) is a secreted glycoprotein encoded by LGALS3BP gene.