For example, expression of GPR56 was higher in the LSC‐enriched fractions in comparison to the nonengrafting bulk leukemic cells with a clear increase in CD34+ LSCs as compared to the CD34− nonengrafting leukemic cells.15 A complementary study found that GPR56 expression was highest in the CD34+ LSC progeny with a LMPP and GMP phenotype.22 Thus, flow cytometry analysis of GPR56 surface expression may be helpful in determining the pool of AML cells with LSC activity at diagnosis. Here, ADGRG1 is linked to acute myeloid leukemia.