In addition, high GPR56 surface expression in CD34+38− leukemic cells correlated with a recently published LSC gene expression signature.15 These results clearly indicate that high GPR56 surface expression allows identification of AML cells with an LSC‐associated gene expression profile and therefore confirm and extend data from Pabst et al,9 who could show high GPR56 expression to be correlated with high repopulation activity of leukemic cells in immunocompromised mice irrespective of their CD34/38 status. The gene discussed is ADGRG1; the disease is acute myeloid leukemia.