Our data therefore corroborate recent findings by Perna et al and Haubner et al, who reported lower percentages of CLL‐1+ cells among CD34+38− LSC as compared to bulk AML cells32, 33 as well as findings that low CLL‐1 expression both at the protein and gene expression level was associated with increased LSC frequency.16 Altogether, these results support the notion that high CLL‐1 expression is not a suitable marker for identification of leukemic cells with LSC activity among AML bulk cells. This evidence concerns the gene CLEC12A and acute myeloid leukemia.