CD34 and acute myeloid leukemia: For example, expression of GPR56 was higher in the LSC‐enriched fractions in comparison to the nonengrafting bulk leukemic cells with a clear increase in CD34+ LSCs as compared to the CD34− nonengrafting leukemic cells.15 A complementary study found that GPR56 expression was highest in the CD34+ LSC progeny with a LMPP and GMP phenotype.22 Thus, flow cytometry analysis of GPR56 surface expression may be helpful in determining the pool of AML cells with LSC activity at diagnosis.