Several surface markers including CD47, CD117, CD123, CLL‐1, TIM‐3, IL1RAP, and JAM‐C have been reported to be up‐regulated on CD34+38− LSCs or to mark AML cells with high repopulating activity in immunocompromised mice.3, 6, 7, 8 Recently, GPR56 (G‐protein coupled receptor 56) and CLL‐1 (C‐type lectin‐like molecule 1, also known as CLEC12A) have drawn particular attention. Here, CLEC12A is linked to acute myeloid leukemia.