However, extracellular LPA levels or other phospholipids are known to increase in response to brain injury.5, 34, 35, 36 Furthermore, changes in LPA concentration and LPA receptor or LPA metabolic enzyme expression have been linked to neurological disorders such as schizophrenia,37, 38 cancer growth, metastasis,32, 39, 40 and neuropathic pain.41, 42 These observations underline the importance of LPA signaling both in normal development and under pathological conditions in the nervous system and suggest that LPA receptors could be drug targets for therapeutic intervention. Here, LPA is linked to nervous system disorder.