To see if larger gene panels perform better than small disease-specific panels for 508 patients with (suspected) HCM we compared the yield of class 4 and 5 variants of our cardiomyopathy gene panel with that of a fictive gene panel of seven genes with a clear association with HCM (MYBPC3, MYH7, TNNT2, TNNI3, TPM1, MYL2, MYL3). The gene discussed is MYBPC3; the disease is cardiomyopathy.