In ovarian cancer cells, NC treatment led to the inhibition of migration and invasion through regulation of MMP-2/9 (Matrix metalloproteinase 2/9) and Skp2 (S-phase kinase-associated protein 2).27, 28 Altogether, without a doubt, NC exerts its anti-tumor activity in various types of human cancers. This evidence concerns the gene SKP2 and neoplasm.