CD8A and neoplasm: Therefore, we hypothesized that these glycoproteins lead to the stimulation of CD8+ T lymphocytes against several tumor-associated antigens, either by the cross-reaction of anti-hemocyanin glycotope antibodies with carbohydrates localized to tumor cell surfaces or by the indirect stimulation of latent specific immune responses (the bystander effect), impairing the immune tolerance of the tumor [25].