In view of this panoply of different atherogenic functions, specific targeting of the detrimental B2 - AT1 receptor axis could be envisaged as a potential approach to treat not only atherosclerosis but also related pro-thrombotic activities triggered by the B2 bradykinin and angiotensin II AT1 receptors (34, 60, 61). Here, KNG1 is linked to atherosclerosis.