Furthermore, beside their role in blood vessel formation, endothelial cells regulate tumor growth through the paracrine release of a variety of endothelial-derived growth factors, adhesion molecules such as intercellular adhesion molecule 1 (ICAM1), VCAM1, E-selectin, P-selectin and hyaluronan, and chemokines, such as IL-8, monocyte chemotactic protein 1 (MCP1), and SDF1. This evidence concerns the gene ICAM1 and neoplasm.