On the other hand, Xiong et al. transfected the human colorectal cancer cell lines SW1116 and HT29 with STAT5 siRNA and the results indicated that STAT5 is involved in promoting cancer cell growth, cell cycle progression, invasion and migration by modifying expression of Bcl-2, p16, p21, E-cadherin, VEGF, MMP, and p27 genes in colorectal cancer (72). This evidence concerns the gene BCL2 and colorectal cancer.