Recently Gamero et al. (96) showed that STAT2 is tumorigenic in the absence of p53, STAT2 knockdown in p53 null tumor cells increased protein levels of the marker of epithelial-mesenchymal transition (EMT), E-cadherin while overexpression of STAT2 in p53 null cells reduced E-cadherin protein. The gene discussed is TP53; the disease is neoplasm.