A novel aptamer-siRNA chimera (Gint4.T-STAT3) was developed to deliver STAT3 siRNA efficiently and subsequently suppressed the expression of STAT3 in PDGFRβ+ glioblastoma multiforme (GBM) cells, through in vitro and in vivo studies, demonstrating that this is an effective strategy (189). The gene discussed is STAT3; the disease is glioblastoma.