STAT3 and neoplasm: Alginate sulfate (AlgS) with STAT3 siRNA were co-assembled and then followed by bioconjugation of N-acetylgalactosamine (GalNAc) which is specific to the asialoglycoprotein receptors that are overly expressed on hepatocytes to produce a novel tumor specific delivery vector (GalNAc-NPs) (187).