There are no reports in the literature associating in situ TNFR1 expression and its SNPs in the uterine cervix and thus, we should infer that the TNFR1 expression can be negatively modulated by HPV infection and TNFR1 biomarkers are discriminatory between normal and SIL cervix and may be used as an indicator for the cervical precancerous lesions progression. The gene discussed is TNFRSF1A; the disease is squamous cell intraepithelial neoplasia.