TNFRSF1A and squamous cell intraepithelial neoplasia: However, a gradated increase in TNFR1-expressing cells with inflammatory cells morphology was observed in the stroma area in all SIL, mainly in HSIL group when compared to LSIL (1.9-fold, p < 0.001) and control groups (2.6-fold, p < 0.001).