Similar to previous reports from SLE and CLE cohorts (7, 35, 36), the IFN-high patient group presented with a higher skin activity score and tended to have a higher disease activity score based on SLEDAI 2K (p < 0.05 and p = 0.1283, respectively, Figure 5B). This evidence concerns the gene IFNA1 and systemic lupus erythematosus.