Anti-parasite antibodies, Foxp3+ regulatory T cells, IL-10 secreting T cells, and tolerance to malaria toxins, such as GPI and hemozoin, have all been postulated to play important roles in the establishment of immune balance during malaria; however, how these responses develop and their relative contribution to infection-induced protection against severe disease, is mostly unknown (5–9, 11, 12). The gene discussed is IL10; the disease is malaria.