Of note, enhanced IL-6 secretion in Unc93b1 mutated vs. Tlr13-deficient BMDMs was observed after infection with MOI 50 (Figures 1A,C,D), potentially by compensatory upregulation of TLR2 following its stimulation to counterbalance the loss of all endosomal TLRs under high bacterial load (Supplementary Figure 4). The gene discussed is TLR2; the disease is infection.