BRD2 and cartilage-hair hypoplasia: Therefore, in men with complete CHH, it would be theoretically advantageous to first maximize proliferation of Sertoli and germ cell and growth of seminiferous tubules by administering FSH-monotherapy prior to the introduction of hCG, so as to prevent premature maturation of a depleted pool of Sertoli cells under the influence of intra-testicular T.