Further, Brassard et al. (2006) demonstrated that a 39% briefer endurance time in patients with HF was correlated with lower oxidative enzymes [citrate synthase (CS), 3-hydroxyacyl-CoA dehydrogenase (HADH)] and greater glycolytic enzymes [phosphofructokinase (PFK)]. The gene discussed is CS; the disease is hydrops fetalis.