HIP14 activity and palmitoylation levels are significantly reduced in brains of YAC128 mice (Singaraja et al., 2011), In addition, Hip14-/- mice recapitulate neuropathological features of HD but is an earlier, developmental phenotype (Singaraja et al., 2011), whereas Hip14L-/- mice reproduce the age-onset, progressive neuropathological features of HD (Sutton et al., 2013); both show reduced interaction with mHtt. Here, ZDHHC17 is linked to Huntington disease.