In this study, we investigated whether palmitoylation of GluN2B contributes to increased 2B-NMDAR extrasynaptic localization in striatal neurons from YAC128 HD mice and explored a role for Htt-associated PATs (HIP14 and HIP14L) in regulating GluN2B palmitoylation. The gene discussed is HTT; the disease is Huntington disease.