In addition to AD, neurofibrillary pathology, which comprises abnormally hyperphosphorylated tau28,29, is also a hallmark of a family of related neurodegenerative diseases called tauopathies, which include, but not limited to, dementia pugilistica or CTE, frontotemporal dementia-tau, corticobasal degeneration, Pick disease, and Guam Parkinsonism dementia complex30,31. This evidence concerns the gene MAPT and Alzheimer disease.