MAPT and Alzheimer disease: However, the pattern of tau accumulation we observed here was restricted in dentate gyrus and damaged cortical area, similar to that observed in CCI in non-transgenic rats55 but different from previous studies in which more broad accumulation of phospho-tau was seen in 3xTg-AD mice with CCI34 and in aged Tg/htau mice with repetitive mild TBI36, possibly due to different lines of transgenic mice or distinct types of TBI employed.