The intra-ARC infusion of sh-Src did not induce any significant change in the expression of Fyn or Lyn in the ARC area (p > 0.05, Dunnett’s post hoc test in one-way ANOVA, Fig. 3e), or Src in either the cerebral cortex or the dorsal horn of the lumbar spinal cord (p > 0.05, see Fig. 3f), indicating that the lentivirus-mediated sh-Src infection in the ARC area was less likely to affect remote CNS areas such as the cerebral cortex and the dorsal horn of the lumbar spinal cord. Here, SRC is linked to infection.