CXCR3 and tuberculosis: It has recently been demonstrated that IP-10 secretion during TB disease originates from infected macrophages and multinucleated giant cells located in the granulomas, and early inactivation of the secreted chemokine by antagonist form of IP-10 which binds to CXCR3 but does not induce signalling, may also play a role in the pathogenesis of TB51,52.