KATP–deficiency in mice (Abcc8−/−) has been reported to cause calcium-associated changes in the beta cell transcriptome23; therefore, we confirmed that the observed loss of HDL-miR-375-3p export was not merely due to decreased miR-375-3p expression in islets isolated from Abcc8−/− mice compared to WT mice. The gene discussed is ABCC8; the disease is hyperinsulinemic hypoglycemia, familial, 4.