KAT5 and breast cancer: Employing a comprehensive scoring system Tip60 staining in a breast cancer tissue microarray (TMA) was graded, by recording a detailed characterisation of Tip60 localisation: nuclear (Nuc), cytoplasmic (Cyto), Double positive (DP; cytoplasmic and nuclear) and Double Negative (DN; no staining in both cytoplasm and nucleus) (Figs 2A,B and S2–3).