Further arguing against a major pathogenic role for oxidized DA species in AAV-hTyr-injected rodents, it has been recently reported by two independent groups44,45 that DA-mediated toxicity in rodents: (i) is only observed in animals displaying additional PD-related alterations, such as DJ-1 deficiency44 or overexpression of PD-linked A53T mutant aSyn45, but not in regular WT animals44,45, in contrast to our results in AAV-hTyr-injected WT rodents; (ii) is dependent on aSyn44,45, in contrast to the dispensability of aSyn that we reported for AAV-hTyr-mediated toxicity. The gene discussed is PARK7; the disease is Parkinson disease.