Similar to different cell-type specific presentations of tau inclusions in tauopathies, pathological α-synuclein can also display distinct neuronal versus glial preferences by aggregating in the form of neuronal Lewy bodies (LB) in Parkinson’s disease and dementia with Lewy bodies, or glial cytoplasmic inclusions (GCIs) in multiple system atrophy (MSA), respectively [10]. Here, MAPT is linked to multiple system atrophy.