Bidirectional signaling of integrin αIIbβ3 also plays an important role in cancer progression through regulating the interaction of integrin αIIbβ3 with the fibrinogen/αvβ3 complex on the surface of tumor cells [8] and/or releasing vascular endothelial growth factor (VEGF) from activated platelets [17]. This evidence concerns the gene VEGFA and neoplasm.