FOXO1 and neoplasm: Importantly, we observed that PPARγ activation in the tumor tissues was in line with the expression of the target gene PTEN, but inversely correlated with the activation of Akt, as indicated by the phosphorylation of Akt (Ser473) and its downstream FoxO1 (Ser256) and Bcl2 (Ser70) (Fig. 6d).