In the present study, we analyzed the BM levels of CX3CL1 in a large cohort of patients with MM and indolent monoclonal gammopathies, and we identified the CX3CL1/CX3CR1 axis as a new player of the vascular microenvironment involved in MM-induced angiogenesis. Here, CX3CL1 is linked to monoclonal gammopathy.