Besides, another similar study from Fang et al. also reported that TRF diet (50 mg/kg) improved insulin sensitivity by upregulating PPAR and uncoupling protein 3 (UCP3) mRNA level in the muscles of non-fasting T1DM male C57BLKS/J-Lepr Db/Db mice [60]. This evidence concerns the gene INS and type 1 diabetes mellitus.