Moreover, based on post-irradiation cell survival, siRNA-mediated Nanog downregulation resulted in significant radiosensitization, whereas Nanog overexpression significantly protected both of the tested breast cancer cell lines against radiotherapy, see Figure 2C. These data confirm the importance of Nanog in both ALDH activity and post-irradiation cell survival. The gene discussed is LDHA; the disease is breast carcinoma.