18FDG-PET technology is based on the fact that a glucose analog (2-deoxyglucose, 2-DOG) can be phosphorylated by mitochondrial HK-II to produce 2-deoxyglucose-6-phosphate (2-DOG-6-P) that is not metabolized further and, thus, accumulates in tumor cells with much higher levels than that in normal cells, in which 2-DOG is radiolabeled with 18F isotope (18FDG). Here, HK2 is linked to neoplasm.