As shown in Figure 5B, the unsupervised hierarchical clustering of EGFR, EGR1, and NAB2 expression values for all 483 patients showed significantly fewer metastatic tumors (53 metastatic/121 total tumors; hypergeometric p = 0.018) in the high EGR1/low NAB cluster, whereas the high EGR1/high NAB2 cluster was associated with significantly more metastatic tumors (53 metastatic/94 total tumors; hypergeometric p = 0.044), with the total cluster number being six (purple line in Figure 5A showing the tree cut). Here, EGR1 is linked to metastatic neoplasm.