The following has been reported: (i) VEGFR3 and its ligand, VEGFC, are responsible for lymphangiogenesis; (ii) VEGFC and VEGFD contribute to tumor angiogenesis by binding to VEGFR2 and VEGFR3; (iii) VEGFR3 is expressed in the tip cells of tumor vessels [15,24]. Here, FLT4 is linked to neoplasm.