CD4 and Irritability: Dexamethasone administered at a dose of 1 mg/kg per day inhibited house dust mite-evoked lung inflammation and airway hyperreactivity, but both dexamethasone and budesonide (7.5 mg/mL) induced a reduction in Treg cell (CD4+CD25+FoxP3+) numbers in the lungs and lymphoid organs of allergen-challenged mice.