KLRK1 and neoplasm: Although we demonstrated that the γδ T-cells + PAM combination treatment caused the susceptibility of tumor cells to γδ T-cell-mediated cytotoxicity via the induction of NKG2D ligands in vitro, our results showed that a systemic injection of PAM 24 h before the adoptive transfer of Vγ9Vδ2 T-cells did not improve therapeutic outcomes compared to Vγ9Vδ2 T-cells alone in vivo.