MAPT and early-onset autosomal dominant Alzheimer disease: Interestingly, these neuroinflammatory responses also lead to neurodegenerative changes, such as tau phosphorylation, cytokine-induced glutamatergic excitotoxicity, synaptic impairment, and most importantly, beta-amyloid accumulation, which are also characteristic of Alzheimer’s disease [22,25,26,101,102].