On the other hand, since activation of TRPV1 expressed on the sensory nerve fibers was shown to be beneficial in SSc because of the release of certain sensory nerves-derived neuropeptides, e.g., calcitonin gene-related peptide [340], it seems to be almost unpredictable what the net effect of TRPV-activating pCBs would be in SSc. Here, TRPV1 is linked to systemic sclerosis.