Of great importance, THC (15 mg/kg/day; p.o.)as well as a “Sativex-like” preparation (7.5 mg/kg/day THC-botanical drug substance [BDS] and equal amount of CBD-BDS, p.o.)were able to substantially inhibit melanoma viability, proliferation, and tumor growth in mice bearing BRAF wild-type melanoma xenografts (CHL-1 cells) [410]. This evidence concerns the gene BRAF and melanoma.