Considering that, in human sebocytes CBD up-regulated TRIB3 in an A2A receptor-dependent manner [120], and that A2A receptors were found to be overexpressed in SSc fibroblasts [75], further studies are invited to dissect if dysregulation of the putative A2A↑→TRIB3↑ pro-fibrotic pathway plays a role in the pathogenesis of SSc. The gene discussed is TRIB3; the disease is systemic sclerosis.