CNR2 and Alzheimer disease: With respect to the “classical” receptors, it is noteworthy that the orally available CB2 agonist S-777469 (1–10 mg/kg) significantly suppressed DNFB-induced ear swelling in BALB/c mice in a dose-dependent manner, and alleviated mite antigen-induced AD-like skin lesions in NC/Nga mice (10–30 mg/kg) as revealed by reduced epidermal thickness, as well as MC and eosinophil numbers.