Partially in line with these data, CB1 mRNA was found to be expressed in 4 human melanoma cell lines (non-metastatic: WM35 or metastatic: HT168, A2068, HT168-M1), and confocal microscopy revealed that CB1 was expressed both at the cell membrane as well as in the cytosol of HT168-M1 cells [394]. The gene discussed is CNR1; the disease is melanoma.