CNR2 and fibrosis: Similarly, in a hypochlorite-induced BALB/c mice fibrosis model, WIN-55,212 (CB1 and CB2 agonist) and JWH-133 (a selective CB2 agonist) prevented the development of skin and lung fibrosis, and reduced fibroblast proliferation as well as the development of anti-DNA topoisomerase I autoantibodies.