Moreover, keratinocyte-specific CB1−/− mice exhibited a stronger pro-inflammatory reaction (higher up-regulation of IL-4, CCL8 [a.k.a. MCP-2], TSLP, and eosinophilic activity) in fluorescein isothiocyanate (FITC)-induced atopic-like inflammation, and showed delayed barrier repair following FITC challenge. The gene discussed is CCL8; the disease is inflammatory response.