CNR2 and neoplasm: Moreover, peritumoral administration of WIN55,212-2 as well as of the selective CB2 agonist JWH-133 could suppress tumor growth and angiogenesis in vivo in NMRI nude mice following subcutaneous flank inoculation of PDV.C57 epidermal tumor cells, most likely via suppressing epidermal growth factor receptor expression and activation (autophosphorylation) [133].