Importantly, elevation of the eCB-tone by PF-3845 (FAAH-inhibitor; 5, 10, and 20 mg/kg, i.p. or 1, 5, and 10 μg, i.t.), JZL184 (MAGL-inhibitor; 4, 20, and 40 mg/kg, i.p. or 1, 5, and 10 μg, i.t.), as well as JZL195 (a dual FAAH/MAGL-inhibitor; 2, 5, and 20 mg/kg, i.p. or 1, 5, and 10 μg, i.t.)exerted potent spinal anti-pruritic effects in a serotonin-induced pruritus model of BALB/c mice [372]. This evidence concerns the gene MGLL and Pruritus.