Moreover the selective A2A receptor agonist CGS-21680 (1 μM; 24 h) increased collagen production, and myofibroblast trans-differentiation (as monitored by α-SMA expression) both in healthy and in SSc fibroblasts, most likely via activating the ERK1/2 MAPK pathway [75]. The gene discussed is ACTA1; the disease is systemic sclerosis.