Since, as mentioned above, besides CB1 and GPR55, AM251 can also target GPR18 [395], one might speculate that modulating activity of this receptor may be responsible for the beneficial effects, especially, since GPR18 (as well as GPR119) was found to be overexpressed at the mRNA level in melanomas as compared to nevi [397]. The gene discussed is GPR55; the disease is melanoma.