Indeed, by using co-cultures of a human melanotic melanoma cell line (SK-mel-1) and HaCaT keratinocytes (a spontaneously immortalized human epidermal keratinocyte cell line [159]), Magina and her co-workers found that CB1 agonism reduced both spontaneous and UVB-induced melanogenesis, highlighting that the local tissue microenvironment may have an important role in regulating melanocyte functions [160]. This evidence concerns the gene CNR1 and melanoma.