THC did not affect vascularization of the tumor, but a reduction in the number of infiltrating CD45+/CD11b+/Gr1- (dominantly macrophages) and CD45+/CD11b+/Gr1+ (dominantly neutrophils) immune cells was observed in wild-type animals, suggesting that certain, yet un-characterized, immunological effects of THC might contribute to its anti-melanoma activity [409]. The gene discussed is ITGAM; the disease is melanoma.