Although the latter seems to be age-dependent (in fact, THC was shown to CB1-dependently improve memory function in aged mice [419], whereas lack of homeostatic CB1 signaling in aged CB1−/− mice led to a premature decline in cognitive abilities [420]), it is important to emphasize that activation of mitochondrial, but not surface membrane, CB1 is responsible for THC-induced memory impairment [81,82]. Here, CNR1 is linked to memory impairment.