Following tumor formation by injecting B16 cells into C57BL/6 mice, peritumoral injections of WIN55,212-2 as well as of the CB2-selective agonist JWH-133 (both at 50 μg/day) suppressed growth, proliferation, angiogenesis and metastasis formation, but increased apoptosis of melanomas in vivo. Here, CNR2 is linked to neoplasm.