CNR2 and fibrosis: Moreover, AEA inhibited FcεRI-dependent degranulation and cytokine synthesis in murine bone marrow-derived MCs via the activation of CB2/GPR55 receptor heteromers [241], and VCE-004.3, as well as VCE-004.8, two PPARγ and CB2 receptor activating derivatives of CBD, could also reduce MC degranulation in bleomycin-induced murine fibrosis [242,243].