In osteosarcoma, isoform 1 acted as a potent suppressant of migration and metastasis through c-Src repression [15,16], while isoform 2-transfected breast cancer cell lines and showed a superior ability to migrate compared to the control, and this difference was not observed in the same cells transfected with the isoform 1 [17,25]. This evidence concerns the gene SRC and osteosarcoma.