In spite of the previous mentioned evidence, we and other groups have recently demonstrated a direct effect of autophagy modulation on migration and invasion capabilities of GBM cells, as illustrated in Figure 1B. Autophagy induction by nutrient deprivation or by mTOR inhibition determines a reversion of EMT phenotype in immortalized and primary GBM cells [146,147,148,149]. Here, MTOR is linked to glioblastoma.