Flavivirus infection of humans, humanized mice, and cell culture often altered levels of glycerophospholipids that curve membranes or control membrane fluidity, such as PI, PE, LPL, and sphingolipids, consistent with the need for flexible, curved membranes for replication spherules and virion envelopes [11,20,22,27,28,85,87,93,121,123,134]. This evidence concerns the gene LPL and Flavivirus Infections.