This finding concurs with the report, which demonstrated that pre-treatment with resveratrol attenuated cognitive impairment and decreased ER stress markers in aged mice [64], as well as the modulatory effects of resveratrol on ER stress in a rat model of PD, restoring locomotor activity [65], through the suppression of ER stress via PERK/EIF2α pathway by resveratrol. This evidence concerns the gene EIF2A and Parkinson disease.