FBXW7 and neoplasm: Several E3 ubiquitin ligases targeting ΔNp63 have been identified so far, e.g. RACK1, NEDD4, ITCH, FBW7 and WWP1, each of them likely contributing to modulate ΔNp63 protein levels in tumours (Bakkers et al., 2005; Fomenkov et al., 2004; Galli et al., 2010; Li et al., 2008; Malatesta et al., 2013; Peschiaroli et al., 2010; Rossi et al., 2006).