Interestingly, EGF‐R expression has been positively correlated with that of HAS3 in human oesophageal SCC tumours (Twarock et al., 2011) and activation of EGF‐R enhances HAS3 expression in some tumour cells (Bourguignon et al., 2007; Chow et al., 2010), implying a positive feedback between EGF‐R signalling and ∆Np63‐HAS3 pathway in HNSCC. Here, HAS3 is linked to head and neck squamous cell carcinoma.