TP63 and head and neck squamous cell carcinoma: In HNSCC cells, it has been showed that ΔNp63 is able to interact with p73, restraining the transcriptional activation of the pro‐apoptotic gene PUMA. Accordingly, down‐modulation of p63 relieves p73 and induces cell death, a phenomenon reversed by the overexpression of BCL‐2, an important anti‐apoptotic protein (Adams and Cory, 2018; Kale et al., 2018; Strasser and Vaux, 2018).