Interestingly, the ability of ΔNp63 to affect NOTCH1 expression negatively has also been observed in the epidermis of ΔNp63 knock‐out mouse embryos (Romano et al., 2012), suggesting that the ΔNp63/NOTCH1 pathway might be indicative of a regenerative state of tumour cells. The gene discussed is NOTCH1; the disease is neoplasm.