Our results suggest that the 14-3-3 proteins could be a marker of neuronal damage, and that the presence of 14-3-3 protein isoforms in the CSF may be the consequence of disruption of the BBB caused by eosinophilic meningitis, as it has been shown that infection by a parasite can induce the up-regulation of MMP-9 [35], vascular endothelial growth factor [36] and hepatocyte growth factor [37], and contribute to the degradation of meningeal blood vessel membranes. This evidence concerns the gene VEGFA and infection.