After analysis of the pooled selected studies, there were no significant associations between the variant T allele (Fig 2A, p-value = 0.10, OR [95%CI] = 0.95 [0.82–1.10]) or the CT+TT genotype (Fig 2B, p-value = 0.16, OR [95%CI] = 0.92 [0.76–1.12]) of the rs243865 MMP-2 polymorphism and the presence of AMD (Fig 2). This evidence concerns the gene MMP2 and age-related macular degeneration.