MMP2 and age-related macular degeneration: We have chosen to analyze the rs243865 polymorphism for two main reasons: (1) it modifies the MMP-2 gene promoter activity and, thus, the extracellular matrix regulation, which may be linked to the development of AMD [5]; and (2) because to the best of our knowledge, the rs243865 MMP-2 polymorphism has not been included in any genome-wide association (GWAS) or meta-analysis studies for AMD.