All the 43 candidate SNVs, except SUSD5: c. 526C>T (pVAASTp-value = 0.21) and SMYD5: c. 662G>A (pVAASTp-value = 0.067), were significantly associated with RA (pVAASTp-value ≤ 0.037). The gene discussed is SMYD5; the disease is rheumatoid arthritis.