Along with the available interventions of diabetes like oral hypoglycemic agents and insulin therapy, many diabetic patients also choose complementary and alternative therapies which have intensified the demand for alternative therapies for management of diabetes [12].Following the direction of using safenatural products along with functional foods, their bioactive constituents and medicinal properties, the present study was designed to investigate petroleum ether extract of C. sativum for attenuation of DN. Here, INS is linked to diabetes mellitus.