MAPK8 and cancer: Interestingly, accumulating evidence suggest an anti-cancer function of Curcumin, and this potential effect of Curcumin has been suggested to work through suppression of growth of cancer cells by inhibition of multiple cell signaling pathways that regulate cell replication (e.g. through CCND1 [10], c-myc [11–14]), that regulate cell survival (e.g. through Bcl-2, Bcl-xL, cFLIP, caspase-8, 3, 9) [15–18], that regulate tumor suppressors (e.g. through p53, p21) [19–23], and that regulate protein kinase pathway (e.g. through JNK, Akt, and AMPK) [24–26].